There is a paucity of evidence of the impact of
sorafenib on MCT and it is the preferred
therapy used in India. We decided to do an audit of all patients of MCT who were referred to us for systemic
therapy. The objective of this exercise was to identify the treatment pattern, outcomes, and adverse events with
therapy in MCT. Baseline demographics (age, gender, ECOG PS, comorbidities, habits),
tumor details (site of
metastasis), previous treatment details, clinical features at
metastasis (symptomatic or asymptomatic), the pattern of treatment, adverse events (CTCAE version 4.02), date of progression, date of death and status, and follow-up were extracted from the rare
tumor database and electronic medical records. Out of 75 patients referred for
therapy for MCT, 47 (62.7%) patients were considered for immediate
tyrosine kinase inhibitors as they had symptomatic status and 28 (37.3%) patients were kept on observation due to the asymptomatic nature of the disease. Out of the 28 patients, 15 (53.6%, n = 28) patients were subsequently started on TKI while in 13 (46.4%, n = 28) patients observation was continued. In the overall cohort, the median PFS was 18.9 months (95% CI 11.9-29.9) and OS was 26.6 months (95% CI 14.4-39.0). Among variables tested, only female gender had an impact on PFS (hazard ratio = 0.364 95% CI 0.148-0.895; P = 0.028) and the absence of lung
metastasis had a positive impact on OS (hazard ratio = 0.443 95% CI 0.207-0.95; P = 0.037). Most commonly used TKI was
sorafenib (n = 61) and
sunitinib in 1 patient. The most common adverse events with TKI were palmo-plantar
dysesthesia (50, 80.6%) and
oral mucositis (25, 40.2%). The strategy of treating symptomatic MCT and observing in asymptomatic MCT is associated with reasonable PFS and OS.
Sorafenib is the most commonly used TKI in our setup and provides similar outcomes as globally.