Central precocious puberty during COVID-19 pandemic and sleep disturbance: an exploratory study.

Abstract

BACKGROUND:

Increased incidence of central precocious puberty (CPP) after coronavirus infectious disease-19 lockdown has been reported. Our study aims in investigating changes in CPP rates and in sleep patterns in CPP and healthy controls.

METHODS:

CPP were retrospectively evaluated from April 2020 to April 2021. Parents of girls diagnosed with CPP during lockdown and of matched healthy controls filled out a questionnaire about sleep disturbances (SDSC questionnaire) and sleep schedules.

RESULTS:

Thirty-five CPP and 37 controls completed the survey. Incidence of new CPP cases significantly increased in 2020-2021 compared to 2017-2020 (5:100 vs 2:100, p = 0.02). Sleep disturbance rates did not differ between CPP and healthy controls before lockdown. During lockdown, CPP reported higher rates of sleep disturbs for total score (p = 0.005), excessive somnolence (p = 0.049), sleep breathing disorders (p = 0.049), and sleep-wake transition disorders (p = 0.005). Moreover, CPP group more frequently shifted toward later bedtime (p = 0.03) during lockdown compared to controls. Hours of sleep and smartphone exposure around bedtime did not differ between groups.

CONCLUSIONS:

Our study confirms the observation of increased incidence of CPP after lockdown measures. Additionally, CPP showed higher rates of sleep disturbances and later bedtime compared to controls. The causality link between sleep disturbances and CPP should be further investigated to gain knowledge in this association.

• Authors: Giuseppina R Umano, Ivan Maddaluno, Simona Riccio, Francesca Lanzaro, Rachele Antignani, Maria Giuliano, Caterina Luongo, Adalgisa Festa, Emanuele Miraglia Del Giudice, Anna Grandone
• Journal: Italian journal of pediatrics (Ital J Pediatr) Vol. 48 Issue 1 Pg. 60 (Apr 23 2022) ISSN: 1824-7288 [Electronic] England
• PMID: 35461296 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Topics

• COVID-19 (epidemiology)
• Communicable Disease Control
• Female
• Humans
• Pandemics
• Puberty, Precocious (epidemiology, etiology)
• Retrospective Studies
• Sleep
• Sleep Wake Disorders (epidemiology, etiology)