Antiproteases and antioxidants: strategies for the pharmacologic prevention of lung destruction.

Abstract

Proteolysis and oxidation are processes which play a central role in the pathogenesis of emphysema. Hereditary factors, including alpha 1-antitrypsin deficiency, and environmental exposures, such as to cigarette smoke, coal dust and bacteria, are associated with a high risk for the development of emphysema through their interactions with proteolytic and oxidative processes within the lung. Because of the key roles of oxidation and proteolysis, reasonable strategies for the prevention of lung destruction in high-risk individuals include such therapeutic interventions as augmentation of lung levels of alpha 1-antitrypsin and the administration of antioxidants.

• Authors: R C Hubbard, R G Crystal
• Journal: Respiration; international review of thoracic diseases (Respiration) Vol. 50 Suppl 1 Pg. 56-73 ( 1986) ISSN: 0025-7931 [Print] Switzerland
• PMID: 3544112 (Publication Type: Journal Article, Review)

Chemical References

• Antioxidants
• Protease Inhibitors
• Peptide Hydrolases

Topics

• Antioxidants (metabolism, therapeutic use)
• Bacterial Infections (complications)
• Environmental Exposure
• Humans
• Oxidation-Reduction (drug effects)
• Peptide Hydrolases (metabolism)
• Protease Inhibitors (metabolism)
• Pulmonary Emphysema (enzymology, prevention & control)
• alpha 1-Antitrypsin Deficiency