Pancreatic
adenocarcinoma is one of the most common malignant
tumors of the digestive system. More than 80% of patients with pancreatic
adenocarcinoma are not diagnosed until late stage and have distant or local
metastases.
AIM: This is a retrospective cohort study. Patients with pancreatic
adenocarcinoma and volunteers without
pancreatic diseases underwent CT perfusion imaging from December 2014 to August 2017 in Huashan Hospital, Fudan University Shanghai, China.
RESULTS: A total number of 35 pancreatic
adenocarcinoma patients and 33 volunteers were enrolled. The relative blood flow (rBF), and relative blood volume (rBV) were significantly lower in patients with pancreatic
adenocarcinoma than in the control group (P < 0.05). Conversely, the relative permeability in patients with pancreatic
adenocarcinoma was significantly higher than that in controls (P < 0.05). In addition, rBF, rBV, and the vascular maturity index (VMI) were significantly lower in grade III-IV pancreatic
adenocarcinoma than in grade I-II pancreatic
adenocarcinoma (P < 0.05).
Vascular endothelial growth factor (
VEGF), CD105-MVD, CD34-MVD, and angiogenesis rate (AR) were significantly higher in grade III-IV pancreatic
adenocarcinoma than in grade I-II pancreatic
adenocarcinoma (P < 0.05). Significant correlations between rBF and
VEGF, CD105-MVD, AR, and VMI (P < 0.01) were observed. Moreover, the levels of rBV were statistically significantly correlated with those of
VEGF, CD105-MVD, CD34-MVD, and VMI (P < 0.01).
CONCLUSION: