Circulating inflammatory biomarkers, adipokines and breast cancer risk-a case-control study nested within the EPIC cohort.
Abstract | BACKGROUND: METHODS: Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios ( ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration. RESULTS: Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to- adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [ leptin: OR = 0.83 (0.68-1.00), leptin-to- adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [ leptin: OR = 1.09 (0.96-1.24), leptin-to- adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)]. CONCLUSIONS:
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Authors | Manon Cairat, Sabina Rinaldi, Anne-Sophie Navionis, Isabelle Romieu, Carine Biessy, Vivian Viallon, Anja Olsen, Anne Tjønneland, Agnès Fournier, Gianluca Severi, Marina Kvaskoff, Renée T Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Matthias B Schulze, Giovanna Masala, Rosario Tumino, Sabina Sieri, Chiara Grasso, Amalia Mattiello, Inger T Gram, Karina Standahl Olsen, Antonio Agudo, Pilar Amiano Etxezarreta, Maria-Jose Sánchez, Carmen Santiuste, Aurelio Barricarte, Evelyn Monninkhof, Anouk E Hiensch, David Muller, Melissa A Merritt, Ruth C Travis, Elisabete Weiderpass, Marc J Gunter, Laure Dossus |
Journal | BMC medicine
(BMC Med)
Vol. 20
Issue 1
Pg. 118
(04 18 2022)
ISSN: 1741-7015 [Electronic] England |
PMID | 35430795
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Adipokines
- Adiponectin
- Biomarkers
- Leptin
- C-Reactive Protein
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Topics |
- Adipokines
- Adiponectin
- Biomarkers
- Body Mass Index
- Breast Neoplasms
(diagnosis, epidemiology)
- C-Reactive Protein
(metabolism)
- Case-Control Studies
- Female
- Humans
- Leptin
- Middle Aged
- Prospective Studies
- Risk Factors
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