New emerging targets in advanced urothelial carcinoma: Is it the primetime for personalized medicine?

Abstract

In recent years the introduction of immunotherapy has importantly changed the treatment landscape of advanced urothelial carcinoma. Several immune checkpoint inhibitors are now the standard of care as maintenance treatment after disease control with platinum-based first-line chemotherapy (avelumab), in subsequent lines (pembrolizumab) or as upfront therapy in platinum-ineligible patients (atezolizumab or pembrolizumab). Moreover, personalized therapy based on tumor molecular features has been developed. Namely, the increasing knowledge of the pathogenesis and molecular pathways underlying cancer development and progression is leading the introduction of target therapies such as the recently approved fibroblastic growth factor receptor (FGFR) inhibitor erdafitinib or the anti-nectin 4 antibody drug-conjugated enfortumab vedotin. Consequently, clinicians face new challenges, such as the choice of the best therapeutic sequence for each patient. The aim of this review is focusing on the emerging treatment options in metastatic urothelial carcinoma and discussing clinical features for choosing therapeutic sequencing.

• Authors: Marco Audisio, Marcello Tucci, Rosario Francesco Di Stefano, Elena Parlagreco, Antonio Ungaro, Fabio Turco, Alessandro Audisio, Lavinia Di Prima, Cinzia Ortega, Massimo Di Maio, Giorgio Vittorio Scagliotti, Consuelo Buttigliero
• Journal: Critical reviews in oncology/hematology (Crit Rev Oncol Hematol) Vol. 174 Pg. 103682 (Jun 2022) ISSN: 1879-0461 [Electronic] Netherlands
• PMID: 35421529 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022. Published by Elsevier B.V.

Chemical References

• Cell Adhesion Molecules

Topics

• Carcinoma, Transitional Cell (drug therapy)
• Cell Adhesion Molecules (therapeutic use)
• Humans
• Immunotherapy
• Precision Medicine
• Urinary Bladder Neoplasms (pathology)