Abstract | BACKGROUND: The etiology of POEMS syndrome and its associated polyneuropathy have not been fully elucidated. The clinical picture of POEMS-associated polyneuropathy and nutritional polyneuropathy due to vitamin B6 (VB6) deficiency are strikingly similar, both being typically sensorimotor, symmetrical, stocking and glove distribution, and more severe in the lower extremities. CASE PRESENTATION: We report two consecutive POEMS patients with VB6 deficiency who showed unusual rapid and drastic recovery of polyneuropathies within 6-8 weeks after oral VB6 supplementation. Case 1 was supplemented with VB6 from time of autologous stem cell transplantation. Polyneuropathy began to improve within one week, and he became walker-free and could walk unaided with a cane within 6 weeks. Case 2 was supplemented with VB6 from time of stem cell harvest, and he became cane-free and his gait almost normalized within two months. Nerve conduction studies were also confirmatory of neurologic recovery in both cases. CONCLUSIONS:
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Authors | Hajime Yasuda, Yoshiki Furukawa, Kenya Nishioka, Makoto Sasaki, Yutaka Tsukune, Shuichi Shirane, Nobutaka Hattori, Miki Ando, Norio Komatsu |
Journal | Hematology (Amsterdam, Netherlands)
(Hematology)
Vol. 27
Issue 1
Pg. 463-468
(Dec 2022)
ISSN: 1607-8454 [Electronic] England |
PMID | 35413228
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Vascular Endothelial Growth Factor A
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Topics |
- Dietary Supplements
- Hematopoietic Stem Cell Transplantation
- Humans
- Male
- POEMS Syndrome
(complications, diagnosis, therapy)
- Transplantation, Autologous
- Vascular Endothelial Growth Factor A
- Vitamin B 6 Deficiency
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