Abstract |
The first enantioselective synthesis of (S)- meptazinol in 14 steps from commercially available ethyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate, being widely used in racemic form for pain treatment, and, en route, the formal synthesis of two anti-Alzheimer's agents are reported. A novel ring expansion of 2-azabicyclo[4.1.0] heptanes, readily available via the stereoselective cyclopropanation of 1,2,3,4-tetrahydropyridine-4-ols, provides an effective entry to 3,3-disubstituted azepanes that represent the core for a variety of approved drugs.
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Authors | Tobias Babl, Oliver Reiser |
Journal | The Journal of organic chemistry
(J Org Chem)
Vol. 87
Issue 9
Pg. 6410-6417
(05 06 2022)
ISSN: 1520-6904 [Electronic] United States |
PMID | 35410473
(Publication Type: Journal Article)
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Chemical References |
- Carboxylic Acids
- Meptazinol
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Topics |
- Carboxylic Acids
- Meptazinol
- Stereoisomerism
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