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Asymmetric Total Synthesis of Meptazinol.

Abstract
The first enantioselective synthesis of (S)-meptazinol in 14 steps from commercially available ethyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate, being widely used in racemic form for pain treatment, and, en route, the formal synthesis of two anti-Alzheimer's agents are reported. A novel ring expansion of 2-azabicyclo[4.1.0]heptanes, readily available via the stereoselective cyclopropanation of 1,2,3,4-tetrahydropyridine-4-ols, provides an effective entry to 3,3-disubstituted azepanes that represent the core for a variety of approved drugs.
AuthorsTobias Babl, Oliver Reiser
JournalThe Journal of organic chemistry (J Org Chem) Vol. 87 Issue 9 Pg. 6410-6417 (05 06 2022) ISSN: 1520-6904 [Electronic] United States
PMID35410473 (Publication Type: Journal Article)
Chemical References
  • Carboxylic Acids
  • Meptazinol
Topics
  • Carboxylic Acids
  • Meptazinol
  • Stereoisomerism

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