The larvae of Echinococcus multilocularis causes
alveolar echinococcosis, which poses a great threat to the public health. However, the molecular mechanisms underlying the host and parasite interactions are still unclear. Exploring the transcriptomic maps of
mRNA,
miRNA and
lncRNA expressed in the liver in response to E. multilocularis
infection will help us to understand its pathogenesis. Using liver perfusion, different cell populations including the hepatic cells, hepatic stellate cells and Kupffer cells were isolated from mice interperitoneally inoculated with protoscoleces. Their transcriptional profiles including lncRNAs,
miRNAs and mRNAs were done by
RNA-seq. Among these cell populations, the most differentially-expressed (DE)
mRNA, lncRNAs and
miRNAs were annotated and may involve in the
pathological processes, mainly including metabolic disorders, immune responses and
liver fibrosis. Following the integrative analysis of 38 differentially-expressed DEmiRNAs and 8 DElncRNAs, the
lncRNA-
mRNA-
miRNA networks were constructed, including
F63-miR-223-3p-Fbxw7/ZFP36/
map1b,
F63-miR-27-5p-Tdrd6/Dip2c/Wdfy4 and IFNgAS1-IFN-γ. These results unveil the presence of several potential
lncRNA-
mRNA-
miRNA axes during E. multilocularis
infection, and further exploring of these axes may contribute to better understanding of the pathogenic mechanisms.