Downregulation of SHMT2 promotes the prostate cancer proliferation and metastasis by inducing epithelial-mesenchymal transition.

Abstract

Serine hydroxymethyltransferase 2 (SHMT2) is a key enzyme that regulates serine/glycine transition; however, its specific function and molecular mechanisms in tumors remain controversial. In this study, we aimed to enhance the understanding in this regard. Through in vitro and in vivo experiments, as well as data analyses using public databases, we investigated the effect of SHMT2 in prostate cancer. Our results indicated that SHMT2 acts as a prostate cancer tumor proliferation suppressor and negatively regulates the aggressive behavior of prostate cancer through activation of epithelial-mesenchymal transition. Additionally, downregulated SHMT2 expression was observed in more advanced prostate cancer phenotypes, and further analysis showed that its depletion promoted proliferation and migration in prostate cancer cell lines. Taken together, our results revealed the function of SHMT2 in prostate cancer and may potentially play a role in the exploration of new therapeutic strategies.

• Authors: Lei Chen, Hailong Liu, Yiyi Ji, Zehua Ma, Kai Shen, Xun Shangguan, Hongyang Qian, Yu Zhao, Chun-Wu Pan, Wei Xue
• Journal: Experimental cell research (Exp Cell Res) Vol. 415 Issue 2 Pg. 113138 (06 15 2022) ISSN: 1090-2422 [Electronic] United States
• PMID: 35398308 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Chemical References

• Glycine Hydroxymethyltransferase

Topics

• Cell Line, Tumor
• Cell Proliferation (genetics)
• Down-Regulation (genetics)
• Epithelial-Mesenchymal Transition (genetics)
• Glycine Hydroxymethyltransferase (genetics, metabolism)
• Humans
• Male
• Neoplasm Metastasis
• Prostatic Neoplasms (genetics)