Treatment of Homozygous Familial Hypercholesterolemia With Evinacumab.

Abstract

Patients with homozygous familial hypercholesterolemia (HoFH) have extremely elevated levels of low-density lipoprotein cholesterol (LDL-C), with premature atherosclerosis and aortic valve disease. Available drug treatments are inadequate, and even with serial apheresis, HoFH patients rarely achieve acceptable LDL-C levels. Evinacumab is a monoclonal antibody against angiopoietin-like protein 3 that lowers LDL-C via a novel receptor-independent mechanism. We describe an Ontario patient with HoFH who for 17 months has been treated with monthly infusions of evinacumab added to pre-existing statin, ezetimibe, and evolocumab therapy. Evinacumab in this HoFH patient was associated with markedly improved LDL-C levels and decreased frequency of apheresis.

• Authors: Natasha Jeraj, Shih-Han S Huang, Brooke A Kennedy, Robert A Hegele
• Journal: CJC open (CJC Open) Vol. 4 Issue 3 Pg. 347-349 (Mar 2022) ISSN: 2589-790X [Electronic] United States
• PMID: 35386132 (Publication Type: Case Reports)
• Copyright: © 2021 The Authors.