Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity.

Abstract

OBJECTIVE:

Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is reportedly linked to the disease activity of rheumatoid arthritis (RA), consistent with our previous study. Therefore, the present study aimed to reproduce the previous results.

RESULTS:

The serum IGFBP-3 level was not significantly different among the three groups according to disease activity based on the DAS28-ESR/CRP (p > 0.05) but was significantly different between the low- and high-disease-activity groups based on the DAS28-CRP (p = 0.036). Meanwhile, the interleukin-6 (IL-6) level moderately correlated with DAS28-CRP (Spearman's rho = 0.583, p < 0.001).

• Authors: Hanna Lee, Young Sun Suh, Sang-Il Lee, Yun-Hong Cheon, Mingyo Kim, Hae Sook Noh, Hyun-Ok Kim
• Journal: BMC research notes (BMC Res Notes) Vol. 15 Issue 1 Pg. 128 (Apr 05 2022) ISSN: 1756-0500 [Electronic] England
• PMID: 35382860 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Insulin-Like Growth Factor Binding Protein 3
• Insulin-Like Growth Factor Binding Proteins
• Interleukin-6
• Insulin-Like Growth Factor I
• C-Reactive Protein

Topics

• Arthritis, Rheumatoid (metabolism)
• C-Reactive Protein (metabolism)
• Humans
• Insulin-Like Growth Factor Binding Protein 3
• Insulin-Like Growth Factor Binding Proteins (metabolism)
• Insulin-Like Growth Factor I (metabolism)
• Interleukin-6