Cisplatin-based
chemotherapy is dominated in several
cancers; however, insufficient therapeutic outcomes and systemic toxicity hamper their clinical applications. Controlled release of
cisplatin and reducing inactivation remains an urgent challenge to overcome. Herein, diselenide-bridged mesoporous organosilica nanoparticles (MON) coated with biomimetic
cancer cell membrane were tailored for coordination responsive controlled
cisplatin delivery and GSH depletion to strengthen Pt-based
chemotherapy.
Cisplatin-loaded MON (MON-Pt) showed high loading capacity due to robust coordination between
selenium and
platinum atoms and preventing premature leakage in normal tissue. MON-Pt exhibited a controlled release of activated
cisplatin in response to the redox tumor microenvironment. Meanwhile, MON-Pt containing redox-responsive diselenide bonds could efficiently scavenge intracellular inactivation agents, such as GSH, to enhance Pt-based
chemotherapy. 4T1
breast cancer cell membranes cloaked MON-Pt (MON-Pt@CM) performed efficient anticancer performance and low in vivo system toxicity due to long blood circulation time and high
tumor accumulation benefiting from the
tumor targeting and immune-invasion properties of the homologic
cancer cell membrane. These results suggest a biomimetic nanocarrier to control release and reduce the inactivation of
cisplatin for efficient and safe Pt-based
chemotherapy by responding and regulating the tumor microenvironment.