Abstract | OBJECTIVES: METHOD: RESULTS: There were 969 patients with a mean age of 43.4 ± 10.8 years. There were 143 patients (14.8%) with remission and 223 (23.1%) patients with low disease activity. Male sex (p = 0.021), positive family history (p = 0.036), and human leukocyte antigen-B27 (p = 0.011) were predictors of remission by ASDAS-CRP. There were 654 patients (67.5%) who did not switch to another drug. The highest BASMI and MASES scores were calculated in patients with very high disease activity (p < 0.05). In patients with drug switching, the disease duration was significantly higher (p < 0.001) and the age at diagnosis was significantly lower (p = 0.016). There were significantly more patients with uveitis and higher scores of MASES and BASMI in patients who switch to another biologic disease-modifying anti-rheumatic drugs (p = 0.003, p = 0.009, and p = 0.004, respectively). CONCLUSIONS: In patients with axSpA, male sex, younger age, and HLA-B27 positivity are associated with remission, while longer disease duration and accompanied uveitis appear to be related with drug switching. CLINICAL TRIAL REGISTRATION NUMBER AND DATE: NCT04139954/25.10.2019.
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Authors | Hatice Bodur, Fatma Gul Yurdakul, Sebnem Ataman, Hasan Fatih Cay, Gulcan Gurer, Erhan Capkin, İlhan Sezer, Mehmet Tuncay Duruoz, Meltem Alkan Melikoglu, Aylin Rezvani, Ilker Yagci, Feride Gogus, Ayhan Kamanli, Ozgur Akgul, Remzi Cevik |
Journal | Clinical rheumatology
(Clin Rheumatol)
Vol. 41
Issue 7
Pg. 2053-2063
(Jul 2022)
ISSN: 1434-9949 [Electronic] Germany |
PMID | 35353263
(Publication Type: Journal Article, Multicenter Study)
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Copyright | © 2022. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR). |
Chemical References |
- Antirheumatic Agents
- Biological Products
- C-Reactive Protein
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Topics |
- Adult
- Antirheumatic Agents
(therapeutic use)
- Axial Spondyloarthritis
- Biological Products
(therapeutic use)
- C-Reactive Protein
(analysis)
- Cross-Sectional Studies
- Drug Substitution
- Female
- Humans
- Male
- Middle Aged
- Registries
- Severity of Illness Index
- Spondylarthritis
(drug therapy)
- Spondylitis, Ankylosing
(diagnosis, drug therapy)
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