Abstract | Background: Case Description: We describe the clinical findings, management, and outcome of a young patient with NF1 who developed aggressive cranial nerve and spinal MPNST tumors. This 35-year-old patient had familial NF1 and a history of optic glioma treated with radiation therapy (RT). She developed a trigeminal MPNST that was resected and treated with RT. Four years later, she developed bilateral lower extremity deficits related to an intramedullary cervical spine tumor, treated surgically, and found to be a second MPNST. Conclusion: To the best of our knowledge, this is the first report of cranial nerve and intramedullary spinal MPNSTs manifesting in a single patient, and only the third report of a confined intramedullary spinal MPNST. This unusual case is discussed in the context of a contemporary literature review.
|
Authors | Christopher Newell, Alan Chalil, Kristopher D Langdon, Vahagn Karapetyan, Matthew O Hebb, Fawaz Siddiqi, Michael D Staudt |
Journal | Surgical neurology international
(Surg Neurol Int)
Vol. 12
Pg. 630
( 2021)
ISSN: 2229-5097 [Print] United States |
PMID | 35350820
(Publication Type: Case Reports)
|
Copyright | Copyright: © 2021 Surgical Neurology International. |