A case report of prucalopride treatment in pediatric gastroparesis: a novel therapy.

Abstract

Prucalopride has been used in adults with gastroparesis, accelerating gastric emptying. There are no studies with this drug in gastroparetic children. An 8-year-old boy is presented who consulted for a month of postprandial symptoms, with a diagnosis of gastroparesis by gastric emptying scintigraphy. He did not improve with metoclopramide, domperidone, erythromycin, and esomeprazole. He received prucalopride for two periods (for 178 and 376 days) at doses: 0.03 - 0.04 mg/ kg/day, presenting improvement in the follow-up with the cardinal gastroparesis symptom index and gastric emptying scintigraphy. Due to the good response, prucalopride may be a therapeutic option in pediatric gastroparesis.

• Authors: Diana P Escobar-Serna, Fernando J Peralta-Palmezano, Juan J Peralta-Palmezano
• Journal: Archivos argentinos de pediatria (Arch Argent Pediatr) Vol. 120 Issue 2 Pg. e98-e101 (Apr 2022) ISSN: 1668-3501 [Electronic] Argentina
• Vernacular Title: Reporte de un caso de tratamiento de gastroparesia pediátrica con prucaloprida: una terapia novedosa.
• PMID: 35338825 (Publication Type: Case Reports)

Chemical References

• Benzofurans
• prucalopride
• Domperidone

Topics

• Adult
• Benzofurans (therapeutic use)
• Child
• Domperidone (therapeutic use)
• Gastric Emptying
• Gastroparesis (diagnosis, drug therapy)
• Humans
• Male