Baicalin promotes the activation of brown and white adipose tissue through AMPK/PGC1α pathway.

Abstract

Obesity occurs when energy intake overtops energy expenditure. Promoting activation of brown adipose tissue (BAT) and white adipose tissue (WAT) has been proven a promising therapeutic strategy for obesity. Baicalin (BAI) has been shown to be protective for various animal models of cardiovascular diseases, such as pulmonary hypertension, atherosclerosis and myocardial hypertrophy. However, whether BAI could stimulate activation of BAT or browning of WAT remains unknown. Here we show that BAI limits weight gaining, ameliorates glucose tolerance, improves cold tolerance and promotes brown-like tissue formation in diet induced obesity mice model. BAI increases the mitochondrial copy number as judged by mtDNA detection. BAI also increases the expression of UCP1 and other classical browning-specific genes in BAT and WAT and cultured C3H10T1/2 adipocytes through a mechanism involving AMPK/PGC1α pathway. Collectively, our study established a role for BAI in regulating energy metabolism, which will provide new idea and theoretical basis for the treatment of obesity.

• Authors: Yanqing Zhang, Zhenzhen Zhang, Yiwei Zhang, Leiming Wu, Lu Gao, Rui Yao, Yanzhou Zhang
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 922 Pg. 174913 (May 05 2022) ISSN: 1879-0712 [Electronic] Netherlands
• PMID: 35337814 (Publication Type: Journal Article)
• Copyright: Copyright © 2022. Published by Elsevier B.V.

Chemical References

• Flavonoids
• Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
• baicalin
• AMP-Activated Protein Kinases

Topics

• AMP-Activated Protein Kinases (metabolism)
• Adipose Tissue, Brown (metabolism)
• Adipose Tissue, White (metabolism)
• Animals
• Diet, High-Fat (adverse effects)
• Energy Metabolism
• Flavonoids
• Mice
• Mice, Inbred C57BL
• Obesity (metabolism)
• Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (genetics, metabolism)
• Thermogenesis (genetics)