Narrative review of local prostate and metastasis-directed radiotherapy in the treatment of metastatic prostate cancer.

Abstract

The role of local treatment in patients with de novo metastatic prostate cancer is controversial. In population-based retrospective studies, metastatic prostate cancer patients who received local treatment with prostate radiotherapy showed a better prognosis than those who did not. In addition, several prospective randomized studies demonstrated that prostate radiotherapy achieves a survival benefit for patients with oligo-metastasis. Moreover, the efficacy of metastasis-directed radiotherapy was evaluated, revealing a potential benefit for patients with oligo-metastasis. Importantly, these radiotherapies may reduce the occurrence of symptomatic local events. In this review, the rationale, efficacy and future perspectives for local prostate and metastasis-directed radiotherapy in the treatment of metastatic prostate cancer were described and summarized.

• Authors: Naoki Terada, Rihito Aizawa, Keiji Nihei, Masaki Shiota, Takahiro Kojima, Takahiro Kimura, Takahiro Inoue, Hiroshi Kitamura, Mikio Sugimoto, Hiroyuki Nishiyama, Takashi Mizowaki, Toshiyuki Kamoto
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 52 Issue 6 Pg. 633-641 (May 31 2022) ISSN: 1465-3621 [Electronic] England
• PMID: 35325157 (Publication Type: Journal Article, Review)
• Copyright: © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].

Topics

• Humans
• Male
• Neoplasm Metastasis (pathology)
• Pelvis (pathology)
• Prospective Studies
• Prostate (pathology)
• Prostatic Neoplasms (pathology)
• Retrospective Studies