Role of Paralogue of XRCC4 and XLF in DNA Damage Repair and Cancer Development.

Abstract

Non-homologous end joining (cNHEJ) is a major pathway to repair double-strand breaks (DSBs) in DNA. Several core cNHEJ are involved in the progress of the repair such as KU70 and 80, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Artemis, X-ray repair cross-complementing protein 4 (XRCC4), DNA ligase IV, and XRCC4-like factor (XLF). Recent studies have added a number of new proteins during cNHEJ. One of the newly identified proteins is Paralogue of XRCC4 and XLF (PAXX), which acts as a scaffold that is required to stabilize the KU70/80 heterodimer at DSBs sites and promotes the assembly and/or stability of the cNHEJ machinery. PAXX plays an essential role in lymphocyte development in XLF-deficient background, while XLF/PAXX double-deficient mouse embryo died before birth. Emerging evidence also shows a connection between the expression levels of PAXX and cancer development in human patients, indicating a prognosis role of the protein. This review will summarize and discuss the function of PAXX in DSBs repair and its potential role in cancer development.

• Authors: Jialin Tang, Zhongxia Li, Qiong Wu, Muhammad Irfan, Weili Li, Xiangyu Liu
• Journal: Frontiers in immunology (Front Immunol) Vol. 13 Pg. 852453 ( 2022) ISSN: 1664-3224 [Electronic] Switzerland
• PMID: 35309348 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2022 Tang, Li, Wu, Irfan, Li and Liu.

Chemical References

• DNA-Binding Proteins
• PAXX protein, human
• XLF protein, mouse
• XRCC4 protein, human
• XRCC4 protein, mouse
• DNA

Topics

• Animals
• DNA
• DNA Breaks, Double-Stranded
• DNA Repair
• DNA-Binding Proteins (genetics)
• Humans
• Mice
• Neoplasms (genetics)