GSTT1, an increased risk factor for prostate cancer in patients with metabolic syndrome.

Abstract

BACKGROUND:

Glutathione S-transferase (GSTs) gene polymorphism and metabolic syndrome (Mets) are generally considered to be risk factors for prostate cancer (PCa). However, this conclusion is still controversial. There is a close relationship between GSTs gene polymorphism and Mets. We suspect that the effect of GSTs gene polymorphism and Mets on PCa may be the result of their joint action. As a result, the purpose of this study was to investigate the potential effect of GSTs gene polymorphism on PCa in patients with Mets.

METHODS:

We collected blood samples from 128 patients with PCa and 200 controls. The GSTs gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Age, characteristics of Mets, frequencies of GSTs gene polymorphism, total prostate volume (TPV), Gleason score, and prostate-specific antigen (PSA) were recorded and analyzed.

RESULTS:

There were significant differences in BMI, TG, LDL-C, FBG, SBP, DBP, and HDL-C among the control group, N-PCa group, and Mets-PCa group (p < 0.05). GSTT1 null genotype (OR = 2.844, 95% CI: 1.791-4.517), GSTM1 null genotype (OR = 2.192, 95% CI: 1.395-3.446), and GSTP1 (A/G + G/G) genotype (OR = 2.315, 95% CI: 1.465-3.657) were associated with PCa susceptibility and malignancy. Only the GSTT1 null genotype in Mets patients was positively correlated with PCa.

CONCLUSIONS:

Our study suggests that GSTs gene polymorphism may be a risk factor for PCa and can predict the susceptibility and malignancy of PCa. Secondly, in Mets patients, GSTT1 null genotype significantly increased the risk of PCa. GSTM1 null genotype and the effect of GSTP1 (AG + GG) on PCa were not significantly related to Mets.

• Authors: Dongdong Liu, Bangwei Che, Pan Chen, Jun He, Yi Mu, Kehang Chen, Wenjun Zhang, Shenghan Xu, Kaifa Tang
• Journal: Journal of clinical laboratory analysis (J Clin Lab Anal) Vol. 36 Issue 4 Pg. e24352 (Apr 2022) ISSN: 1098-2825 [Electronic] United States
• PMID: 35293017 (Publication Type: Journal Article)
• Copyright: © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.

Chemical References

• glutathione S-transferase T1
• Glutathione S-Transferase pi
• Glutathione Transferase

Topics

• Case-Control Studies
• Genetic Predisposition to Disease (genetics)
• Genotype
• Glutathione S-Transferase pi (genetics)
• Glutathione Transferase (genetics)
• Humans
• Male
• Metabolic Syndrome (complications, epidemiology, genetics)
• Prostatic Neoplasms (epidemiology, genetics)
• Risk Factors