Abstract |
Primary ventricular fibrillation (PVF) is a major driver of cardiac arrest in the acute phase of ST-segment elevation myocardial infarction ( STEMI). Enrichment of cardiomyocyte plasma membranes with dietary polyunsaturated fatty acids (PUFA) reduces vulnerability to PVF experimentally, but clinical data are scarce. PUFA status in serum phospholipids is a valid surrogate biomarker of PUFA status in cardiomyocytes within a wide range of dietary PUFA. In this nested case-control study (n = 58 cases of STEMI-driven PVF, n = 116 control non-PVF STEMI patients matched for age, sex, smoking status, dyslipidemia, diabetes mellitus and hypertension) we determined fatty acids in serum phospholipids by gas-chromatography, and assessed differences between cases and controls, applying the Benjamini-Hochberg procedure on nominal P-values to control the false discovery rate (FDR). Significant differences between cases and controls were restricted to linoleic acid (LA), with PVF patients showing a lower level (nominal P = 0.002; FDR-corrected P = 0.027). In a conditional logistic regression model, each one standard deviation increase in the proportion of LA was related to a 42% lower prevalence of PVF (odds ratio = 0.58; 95% confidence interval, 0.37, 0.90; P = 0.02). The association lasted after the inclusion of confounders. Thus, regular consumption of LA-rich foods (nuts, oils from seeds) may protect against ischemia-driven malignant arrhythmias.
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Authors | Teresa Oliveras, Iolanda Lázaro, Ferran Rueda, Germán Cediel, Deepak L Bhatt, Montserrat Fitó, Francisco Madrid-Gambin, Oscar J Pozo, William S Harris, Cosme García-García, Aleix Sala-Vila, Antoni Bayés-Genís |
Journal | Scientific reports
(Sci Rep)
Vol. 12
Issue 1
Pg. 4377
(03 14 2022)
ISSN: 2045-2322 [Electronic] England |
PMID | 35288655
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Fatty Acids, Unsaturated
- Phospholipids
- Linoleic Acid
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Topics |
- Case-Control Studies
- Fatty Acids, Unsaturated
- Humans
- Linoleic Acid
- Myocardial Infarction
(epidemiology)
- Phospholipids
- ST Elevation Myocardial Infarction
(epidemiology)
- Ventricular Fibrillation
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