Effects of Sevoflurane and Propofol on Posttraumatic Stress Disorder After Emergency Trauma: A Double-Blind Randomized Controlled Trial.

Abstract

Objective:

Posttraumatic stress disorder (PTSD) is a frequent and disabling consequence of traumatic events. A previous study found that early use of propofol was a potential risk factor for PTSD. This prospective study aimed to investigate the effect of propofol and sevoflurane on PTSD after emergency surgery in trauma patients.

Methods:

A total of 300 trauma patients undergoing emergency surgery were randomly divided into two groups and anesthetized with propofol and/or sevoflurane. Perioperative clinical data were collected. The incidence of PTSD was evaluated with the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) in the two groups 1 month after the operation. The relevance of the injury time and CAPS-5 scores was assessed by Spearman correlation analysis. Logistic regression analysis was used to analyze the risk factors for PTSD.

Results:

The incidence of PTSD in the propofol group was higher than that in the sevoflurane group 1 month postoperatively (23.2 vs. 12.2%, P = 0.014). The injury time was negatively correlated with the CAPS-5 score in the propofol group (r = -0.226, P < 0.001). In the logistic regression analysis, the utilization of propofol was an independent risk factor for PTSD (P = 0.017).

Conclusion:

Early use of propofol general anesthesia in emergency surgery for trauma patients may increase the risk of PTSD.

Clinical Trial Registration:

www.chictr.org.cn, identifier: ChiCTR2100050202.

• Authors: Junfeng Zhong, Yan Li, Lichao Fang, Dan Han, Chuhao Gong, Shuangyan Hu, Rongguo Wang, Liwei Wang, Rui Yao, Beiping Li, Yangzi Zhu, Youjia Yu
• Journal: Frontiers in psychiatry (Front Psychiatry) Vol. 13 Pg. 853795 ( 2022) ISSN: 1664-0640 [Print] Switzerland
• PMID: 35280171 (Publication Type: Case Reports)
• Copyright: Copyright © 2022 Zhong, Li, Fang, Han, Gong, Hu, Wang, Wang, Yao, Li, Zhu and Yu.