[Effects of horse-chestnut seed extract on transcapillary filtration in chronic venous insufficiency].

Abstract

The effect of horse-chestnut seed extract (standardized on aescin; Venostasin retard) was assessed in a randomized placebo-controlled crossover double-blind trial of 22 patients with proven chronic venous insufficiency by measuring the capillary filtration coefficient and the intravascular volume of the lower leg by venous-occlusion plethysmography. Three hours after taking two capsules of Venostasin (600 mg; each capsule containing 50 mg aescin) the capillary filtration coefficient had decreased by 22%, whereas after administration of an identical-looking placebo capsule it rose but slightly over three hours. The difference in the effect of Venostasin and placebo is statistically significant (P = 0.006). The intravascular volume was reduced 5% more after Venostasin than the placebo, but this is not statistically significant. It is concluded that Venostasin has an inhibitory effect on oedema formation via a decrease in transcapillary filtration and thus improves oedema-related symptoms in venous diseases of the legs.

• Authors: H Bisler, R Pfeifer, N Klüken, P Pauschinger
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 111 Issue 35 Pg. 1321-9 (Aug 29 1986) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Wirkung von Rosskastaniensamenextrakt auf die transkapilläre Filtration bei chronischer venöser Insuffizienz.
• PMID: 3527643 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Plant Extracts
• Saponins
• venostasin
• Escin

Topics

• Capillary Permeability (drug effects)
• Chronic Disease
• Clinical Trials as Topic
• Double-Blind Method
• Drug Combinations (pharmacology, therapeutic use)
• Escin (pharmacology, therapeutic use)
• Female
• Humans
• Middle Aged
• Plant Extracts (pharmacology, therapeutic use)
• Random Allocation
• Saponins (therapeutic use)
• Venous Insufficiency (drug therapy, physiopathology)