Povidone-Iodine as a Pre-Procedural Mouthwash to Reduce the Salivary Viral Load of SARS-CoV-2: A Systematic Review of Randomized Controlled Trials.

Abstract

The use of pre-procedural rinses has been investigated to reduce the number of viral particles and bacteria in aerosols, potentially decreasing the risk of cross-infection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during medical and dental procedures. This review aims to confirm whether there is evidence in the literature describing a reduction in salivary load of SARS-CoV-2 when povidone-iodine (PVP-I) is used as a pre-intervention mouthwash. An search of the MEDLINE, Embase, SCOPUS, and the Cochrane library databases was conducted. The criteria used followed the PRISMA® Statement guidelines. Randomized controlled trials investigating the reduction of salivary load of SARS-CoV-2 using PVP-I were included. Ultimately, four articles were included that met the established criteria. According to the current evidence, PVP-I is effective against SARS-CoV-2 in saliva and could be implemented as a rinse before interventions to decrease the risk of cross-infection in healthcare settings.

• Authors: Alvaro Garcia-Sanchez, Juan-Francisco Peña-Cardelles, Esther Ordonez-Fernandez, María Montero-Alonso, Naresh Kewalramani, Angel-Orión Salgado-Peralvo, Dániel Végh, Angélica Gargano, Gabriela Parra, Lourdes-Isabela Guerra-Guajardo, Wataru Kozuma
• Journal: International journal of environmental research and public health (Int J Environ Res Public Health) Vol. 19 Issue 5 (Mar 01 2022) ISSN: 1660-4601 [Electronic] Switzerland
• PMID: 35270569 (Publication Type: Journal Article, Review, Systematic Review)

Chemical References

• Mouthwashes
• Povidone-Iodine

Topics

• COVID-19 (prevention & control)
• Humans
• Mouthwashes
• Povidone-Iodine (therapeutic use)
• Randomized Controlled Trials as Topic
• SARS-CoV-2
• Viral Load