Abstract | BACKGROUND: METHODS: RESULTS: Among 154 patients included, postoperative atrial fibrillation occurred in 15 of 78 who received N-acetylcysteine (19%) and 13 of 76 who received placebo (17%; odds ratio, 1.24; 95.1% CI, 0.53 to 2.88; P = 0.615). The trial was stopped at the interim analysis because of futility. Of the 28 patients with postoperative atrial fibrillation, 3 (11%) were discharged in atrial fibrillation. Regardless of treatment at 1 yr, 7 of 28 patients with postoperative atrial fibrillation (25%) had recurrent episodes of atrial fibrillation. Inflammatory and oxidative stress markers were similar between groups. CONCLUSIONS: EDITOR’S PERSPECTIVE:
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Authors | David Amar, Hao Zhang, Mina K Chung, Kay See Tan, Dawn Desiderio, Bernard J Park, Alessia Pedoto, Nancy Roistacher, James M Isbell, Daniela Molena, Ginger L Milne, Bryan F Meyers, Gregory W Fischer, Valerie W Rusch, David R Jones |
Journal | Anesthesiology
(Anesthesiology)
Vol. 136
Issue 6
Pg. 916-926
(06 01 2022)
ISSN: 1528-1175 [Electronic] United States |
PMID | 35263434
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022, the American Society of Anesthesiologists. All Rights Reserved. |
Chemical References |
- Anti-Arrhythmia Agents
- Amiodarone
- Acetylcysteine
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Topics |
- Acetylcysteine
(therapeutic use)
- Amiodarone
(therapeutic use)
- Anti-Arrhythmia Agents
(therapeutic use)
- Atrial Fibrillation
(epidemiology, etiology, prevention & control)
- Coronary Artery Bypass
(adverse effects)
- Double-Blind Method
- Humans
- Inflammation
(complications)
- Postoperative Complications
(drug therapy, epidemiology, prevention & control)
- Thoracic Surgery
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