Little is known about the use of
antioxidants in the clinical treatment of
vitiligo. To investigate the specific use of
antioxidants in the treatment of
vitiligo and the possible reasons behind its use in China, we conducted a prospective questionnaire-based study using an online questionnaire comprising 26 questions in 5 areas. A total of 323 clinical frontline dermatologists participated in this study. Differences among groups were compared using Pearson's chi-square test. Ordinal logistic regression was used to develop knowledge-use multiple regression models. Among the 323 dermatologists, 293 (90.7%) approved the oxidative stress theory of
vitiligo, and 182 (56.3%) encouraged the use of
antioxidants for treating
vitiligo; nonetheless, only 11.8% frequently treated
vitiligo with
antioxidants. Insufficient knowledge of
antioxidants was a significant predictor of lower frequency of
antioxidant usage (adjusted odds ratio, 0.401 [95% confidence interval, 0.256-0.629]; P < .001). The predictors associated with higher
antioxidant efficacy included advanced or rapid progression, moderate or moderate-to-severe
vitiligo, age of 0-2 years or 13-18 years, segmental
vitiligo, oral and topical combination
therapy, and course duration of <1 month. The use of
antioxidants for treating
vitiligo is highly encouraged; however, the rates of their clinical use are considerably low. Insufficient knowledge of
antioxidants is associated with a lower frequency of
antioxidant usage. The synergistic curative efficacy of
antioxidants could be affected by the stage, type, severity, age of patients with
vitiligo, and method of using
antioxidants.