Abstract |
Resident memory T lymphocytes (TRM ) of epithelial tissues and the Bm protect their host tissue. To what extent these cells are mobilized and contribute to systemic immune reactions is less clear. Here, we show that in secondary immune reactions to the measles- mumps- rubella ( MMR) vaccine, CD4+ TRM are mobilized into the blood within 16 to 48 h after immunization in humans. This mobilization of TRM is cognate: TRM recognizing other antigens are not mobilized, unless they cross-react with the vaccine. We also demonstrate through methylome analyses that TRM are mobilized from the Bm. These mobilized cells make significant contribution to the systemic immune reaction, as evidenced by their T-cell receptor Vβ clonotypes represented among the newly generated circulating memory T-cells, 14 days after vaccination. Thus, TRM of the Bm confer not only local, but also systemic immune memory.
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Authors | Carla Cendón, Weijie Du, Pawel Durek, Yuk-Chien Liu, Tobias Alexander, Lindsay Serene, Xinyi Yang, Gilles Gasparoni, Abdulrahman Salhab, Karl Nordström, Tina Lai, Axel R Schulz, Anna Rao, Gitta A Heinz, Ana L Stefanski, Anne Claußnitzer, Katherina Siewert, Thomas Dörner, Hyun-Dong Chang, Hans-Dieter Volk, Chiara Romagnani, Zhihai Qin, Sebastian Hardt, Carsten Perka, Simon Reinke, Jörn Walter, Mir-Farzin Mashreghi, Kevin Thurley, Andreas Radbruch, Jun Dong |
Journal | European journal of immunology
(Eur J Immunol)
Vol. 52
Issue 5
Pg. 737-752
(05 2022)
ISSN: 1521-4141 [Electronic] Germany |
PMID | 35245389
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. |
Chemical References |
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Topics |
- Bone Marrow
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Humans
- Immunologic Memory
- Vaccines
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