The role of vitamin D in cardiovascular disease and COVID-19.

Abstract

Patients with pre-existing cardiovascular disease (CVD) are at high risk for adverse outcomes with coronavirus disease 2019 (COVID-19). Further, COVID-19 infection is associated with numerous cardiovascular (CV) complications including arrhythmia, myocardial injury, cardiomyopathy, and thrombotic events. Increased susceptibility to COVID-19 and CV complications related to COVID-19 may be in part related to immune dysregulation and inflammation associated with CV disease which is exacerbated with viral infection. Vitamin D plays a major role in immune function and exerts anti-inflammatory effects, which may prove important in the context of CVD and COVID-19. To date, studies have shown minimal benefit for vitamin D supplementation in patients with COVID-19, though there are no studies specific to patients with CVD and related complications. Further, given that vitamin D has important protective effects on the CV system, including augmentation of myocardial contractility and anti-thrombotic effects, it is unknown if supplementation with vitamin D can mitigate CVD complications associated with COVID-19.

• Authors: Elissa Driggin, Mahesh V Madhavan, Aakriti Gupta
• Journal: Reviews in endocrine & metabolic disorders (Rev Endocr Metab Disord) Vol. 23 Issue 2 Pg. 293-297 (04 2022) ISSN: 1573-2606 [Electronic] Germany
• PMID: 35233703 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Vitamins
• Vitamin D

Topics

• COVID-19 (complications)
• Cardiovascular Diseases (etiology, prevention & control)
• Humans
• Vitamin D (physiology, therapeutic use)
• Vitamin D Deficiency (complications, drug therapy)
• Vitamins (therapeutic use)
• COVID-19 Drug Treatment