Isolated Gastritis Secondary to Immune Checkpoint Inhibitors Complicated by Superimposed Cytomegalovirus Infection.

Abstract

Immune checkpoint inhibitors such as nivolumab increase the T-cell destruction of malignancies but can also trigger a broad variety of immune-related adverse events (irAEs). Colitis as an irAE is well-documented, but upper gastrointestinal tract involvement is primarily unrecognized. We present a patient who developed gastritis as an irAE after multiple cycles of nivolumab and initially responded well to steroid therapy but then developed superimposed cytomegalovirus infection. The similarity between both presentations highlights the importance of having a broad differential diagnosis in patients with gastrointestinal complaints treated with immune checkpoint inhibitors and the need for further studies to better characterize gastritis as an irAE.

• Authors: Anita H Nguyen, Babak Torabi Sagvand, Daniel G Hwang, Teklu Legesse, Raymond K Cross
• Journal: ACG case reports journal (ACG Case Rep J) Vol. 9 Issue 2 Pg. e00747 (Feb 2022) ISSN: 2326-3253 [Print] United States
• PMID: 35224125 (Publication Type: Case Reports)
• Copyright: © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.