Adverse reactions of ALA-PDT for the treatment of cutaneous diseases: A retrospective study.

Abstract

BACKGROUND:

5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) is an effective therapy for cutaneous diseases, such as precancers, superficial non melanoma skin cancers and certain inflammatory or viral conditions. However, the absence of a complete picture of adverse reactions limits the promotion of ALA-PDT.

OBJECTIVE:

To systemically investigate the detailed evidence of adverse reactions relating to ALA-PDT for skin diseases.

METHODS:

A retrospective study performed at the Shanghai Skin Disease Hospital.

RESULTS:

In the retrospective study, 439 patients were included. Incidences of adverse reactions, including in-treatment pain (98.8%), erythema (92.4%), edema (35.0%), exudation (23.0%), hyperpigmentation (27.3%) were clarified. Edema was more common in female patients (P<0.05). Patients with HPV-related skin diseases were more likely to suffer erythema, edema or exudation (P<0.05). Hyperpigmentation was more likely to occur in skin appendage disorders (P<0.05). Fever (2.4%) and hypopigmentation (1.9%) are two neglected adverse reactions analyzed in detail. Fever is more prevalent in female patients. Hypopigmentation occurred predominantly in elderly with skin cancer or precancerosis lesions.

CONCLUSION:

The results outline detailed information about the adverse reactions, including systemic reactions following ALA-PDT, assisting dermatologists in predicting and managing adverse reactions for greater efficacy and higher patient satisfaction.

• Authors: Lei Shi, Jiayi Yang, Linglin Zhang, Yunfeng Zhang, Guorong Yan, Haiyan Zhang, Jin Yang, Peiru Wang, Guolong Zhang, Zhongxia Zhou, Xiuli Wang
• Journal: Photodiagnosis and photodynamic therapy (Photodiagnosis Photodyn Ther) Vol. 38 Pg. 102783 (Jun 2022) ISSN: 1873-1597 [Electronic] Netherlands
• PMID: 35218941 (Publication Type: Journal Article)
• Copyright: Copyright © 2022. Published by Elsevier B.V.

Chemical References

• Photosensitizing Agents
• Aminolevulinic Acid

Topics

• Aged
• Aminolevulinic Acid (adverse effects)
• China
• Erythema (chemically induced, drug therapy)
• Female
• Humans
• Hyperpigmentation (chemically induced, drug therapy)
• Hypopigmentation (chemically induced, drug therapy)
• Photochemotherapy (methods)
• Photosensitizing Agents (adverse effects)
• Retrospective Studies