Multicenter study comparing 0.05% gel formulations of desoximetasone and fluocinonide in patients with scalp psoriasis.

Abstract

A double-blind, multicenter study was conducted to evaluate and compare the safety and efficacy of desoximetasone gel 0.05% and fluocinonide gel 0.05% in patients with scalp psoriasis. One hundred twenty-five patients were enrolled in this randomized, parallel-group trial. Responses based on clinical assessment in 123 patients showed that the desoximetasone gel formulation is a safe and effective treatment for psoriasis of the scalp. Although efficacy appears equivalent to that of fluocinonide gel 0.05% in treating psoriasis of the scalp, desoximetasone appears to be slightly better tolerated and better accepted cosmetically.

• Authors: I Willis, R C Cornell, N S Penneys, N Zaias
• Journal: Clinical therapeutics (Clin Ther) Vol. 8 Issue 3 Pg. 275-82 ( 1986) ISSN: 0149-2918 [Print] United States
• PMID: 3521856 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Gels
• Fluocinolone Acetonide
• Fluocinonide
• Desoximetasone
• Dexamethasone

Topics

• Administration, Topical
• Adolescent
• Adult
• Aged
• Clinical Trials as Topic
• Desoximetasone (administration & dosage, adverse effects, therapeutic use)
• Dexamethasone (analogs & derivatives)
• Double-Blind Method
• Female
• Fluocinolone Acetonide (analogs & derivatives)
• Fluocinonide (administration & dosage, adverse effects, therapeutic use)
• Gels
• Humans
• Male
• Middle Aged
• Psoriasis (drug therapy)
• Scalp Dermatoses (drug therapy)