Testosterone Treatment As a Function-Promoting Therapy in Sarcopenia Associated with Aging and Chronic Disease.

Abstract

Sarcopenia is characterized by loss of muscle strength and physical ability because of aging and/or chronic disease. Supplemental testosterone and other androgenic-anabolic steroids have been investigated as countermeasures to ameliorate the negative consequences of sarcopenia; these trials show dose-related improvements in lean body mass, maximal voluntary strength, stair climbing power, aerobic capacity, hemoglobin, and self-reported function, but less consistent improvements in walking speed. Randomized clinical trials with large cohorts and patient-important outcome measures are needed to determine long-term efficacy and safety of testosterone treatment in improving physical function and reducing physical disability, falls, and fractures in older adults with sarcopenia.

• Authors: Marcelo Rodrigues Dos Santos, Thomas W Storer
• Journal: Endocrinology and metabolism clinics of North America (Endocrinol Metab Clin North Am) Vol. 51 Issue 1 Pg. 187-204 (03 2022) ISSN: 1558-4410 [Electronic] United States
• PMID: 35216716 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Review)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Testosterone

Topics

• Aged
• Aging
• Body Composition (physiology)
• Chronic Disease
• Double-Blind Method
• Humans
• Muscle, Skeletal (physiology)
• Sarcopenia (drug therapy, etiology)
• Testosterone (adverse effects)