Podophyllin in Dermatology: Revisiting a Historical Drug.

Abstract

Podophyllin is a cytotoxic material extracted from Podophyllum peltatum and Podophyllum hexandrum and is widely used for the treatment of genital warts. This article reviews the chemistry of podophyllin and its active components along with the mechanism of action in various dermatoses. Furthermore, the documented uses of podophyllin in various dermatological disorders have been described along with the side effects of the drug. Based on the available literature, a clinical guideline is being proposed so as to minimize the side effects. Further studies should be carried out on its use in a lower concentration in other dermatoses, especially premalignant and malignant skin diseases.

• Authors: Ajeet Singh, Ritul Choudhary, Satyaki Ganguly
• Journal: Indian dermatology online journal (Indian Dermatol Online J) 2022 Jan-Feb Vol. 13 Issue 1 Pg. 167-171 ISSN: 2229-5178 [Print] India
• PMID: 35198500 (Publication Type: Journal Article)
• Copyright: Copyright: © 2022 Indian Dermatology Online Journal.