Vitamin K dietary intake is associated with cognitive function in an older adult Mediterranean population.

Abstract

BACKGROUND:

In the last years, evidence that dietary vitamin K could have a role in the cognitive domain has increased. However, data from large trials are limited. The objective of this study was to assess the association of 2 year changes in the dietary intake of vitamin K with cognitive function measured through neuropsychological performance tests.

METHODS:

In 5,533 participants of the multicentre PREDIMED-Plus study (48.1% women, age 65.1 ± 4.9 years with overweight/obesity and metabolic syndrome), we assessed the adjusted odds ratios of cognitive function decline according to 2 year changes in vitamin K intake. Participants answered a battery of cognitive function tests and Food Frequency Questionnaires (FFQs) in order to estimate the vitamin K dietary intake.

RESULTS:

After adjusting for potential cofounders, the highest tertile of change of dietary vitamin K intake (median [IQR]; 194.4 μg/d [120.9, 373.1]) was inversely associated with a Mini-Mental State Examination (MMSE) score ≤24 (OR [95% CI]; 0.53 [0.35, 0.79] P for trend = 0.002) compared with a decrease in the intake of vitamin K (median [IQR]; -97.8 μg/d [-292.8, -51.5]). A significant positive association between changes in dietary vitamin K intake and the semantic verbal fluency test scores (OR [95% CI]; 0.69 [0.51, 0.94] P for trend = 0.019) was found.

CONCLUSIONS:

An increase of the intake of dietary vitamin K was associated with better cognitive function scores, independently of recognised risk factors for cognitive decline, in an older adult Mediterranean population with high cardiovascular risk.

• Authors: Lucía Camacho-Barcia, Jesús García-Gavilán, Miguel Ángel Martínez-González, Fernando Fernández-Aranda, Serena Galié, Dolores Corella, Aida Cuenca-Royo, Dora Romaguera, Jesús Vioque, Ángel M Alonso-Gómez, Julia Wärnberg, J Alfredo Martínez, Luís Serra-Majem, Ramón Estruch, M Rosa Bernal-López, José Lapetra, Xavier Pintó, Josep A Tur, Antonio Garcia-Rios, Aurora Bueno-Cavanillas, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín-Sánchez, Josep Vidal, Clotilde Vázquez, Emilio Ros, Miguel Ruiz Canela, Jose V Sorlí, Rafael de la Torre, Jadwiga Konieczna, Alejandro Oncina-Cánovas, Lucas Tojal-Sierra, Jessica Pérez-López, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Cristina Bouzas, Cristina Razquin, Raúl Martínez-Lacruz, Olga Castañer, Aina M Yañez, Rafael Valls-Enguix, Maria Concepción Belló-Mora, Javier Basterra-Gortari, Josep Basora, Jordi Salas-Salvadó, Mònica Bulló
• Journal: Age and ageing (Age Ageing) Vol. 51 Issue 2 (02 02 2022) ISSN: 1468-2834 [Electronic] England
• PMID: 35180284 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: [email protected].

Chemical References

• Vitamin K

Topics

• Aged
• Cognition
• Eating
• Female
• Humans
• Male
• Middle Aged
• Neuropsychological Tests
• Nutritional Status
• Vitamin K