Plasma neurofilament light chain protein is not increased in treatment-resistant schizophrenia and first-degree relatives.
Abstract | OBJECTIVE: METHODS: This study measured plasma neurofilament light chain protein (NfL) using ultrasensitive Simoa technology, to investigate the degree of neuronal injury in a well-characterised cohort of people with treatment-resistant schizophrenia on clozapine (n = 82), compared to first-degree relatives (an at-risk group, n = 37), people with schizophrenia not treated with clozapine (n = 13), and age- and sex-matched controls (n = 59). RESULTS: We found no differences in NfL levels between treatment-resistant schizophrenia (mean NfL, M = 6.3 pg/mL, 95% confidence interval: [5.5, 7.2]), first-degree relatives (siblings, M = 6.7 pg/mL, 95% confidence interval: [5.2, 8.2]; parents, M after adjusting for age = 6.7 pg/mL, 95% confidence interval: [4.7, 8.8]), controls (M = 5.8 pg/mL, 95% confidence interval: [5.3, 6.3]) and not treated with clozapine (M = 4.9 pg/mL, 95% confidence interval: [4.0, 5.8]). Exploratory, hypothesis-generating analyses found weak correlations in treatment-resistant schizophrenia, between NfL and clozapine levels (Spearman's r = 0.258, 95% confidence interval: [0.034, 0.457]), dyslipidaemia (r = 0.280, 95% confidence interval: [0.064, 0.470]) and a negative correlation with weight (r = -0.305, 95% confidence interval: [-0.504, -0.076]). CONCLUSION:
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Authors | Dhamidhu Eratne, Shorena Janelidze, Charles B Malpas, Samantha Loi, Mark Walterfang, Antonia Merritt, Ibrahima Diouf, Kaj Blennow, Henrik Zetterberg, Brandon Cilia, Cassandra Wannan, Chad Bousman, Ian Everall, Andrew Zalesky, Mahesh Jayaram, Naveen Thomas, Samuel F Berkovic, Oskar Hansson, Dennis Velakoulis, Christos Pantelis, Alexander Santillo, MiND Study Group |
Journal | The Australian and New Zealand journal of psychiatry
(Aust N Z J Psychiatry)
Vol. 56
Issue 10
Pg. 1295-1305
(10 2022)
ISSN: 1440-1614 [Electronic] England |
PMID | 35179048
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Neurofilament Proteins
- Clozapine
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Topics |
- Alzheimer Disease
(metabolism)
- Biomarkers
- Child
- Clozapine
(therapeutic use)
- Frontotemporal Dementia
(metabolism)
- Humans
- Intermediate Filaments
- Neurodegenerative Diseases
- Neurofilament Proteins
- Schizophrenia
(metabolism)
- Schizophrenia, Treatment-Resistant
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