Melanoma is the most lethal
malignancy in
skin cancer and may occur at any site and express melanocytes. Due to
malignant melanoma's invasion and migration nature, conventional
therapies make it challenging to remove the whole
tumor tissue while undertaking the high risks of
tumor recurrence. Regarding the emerging targeted
therapies and
immunotherapy, drug resistance and low immunotherapeutic activity remain significant challenges. It is thus becoming urgently important to develop alternative strategies for
melanoma therapy. Herein, a novel bifunctional
protein-based photothermal bioplaster (
PPTB) is developed for non-invasive
tumor therapy and skin tissue regeneration. The complexation of adhesive
protein and
gold nanorods (GNRs) endow the obtained
PPTB with good biocompatibility, controllable near-infrared (NIR) light-mediated adhesion performance, and high photothermal performance. Therefore, the
PPTB bioagent facilitates skin adhesion and effectively transfers heat from skin to
tumor. This behavior endows
PPTB capability to eradicate skin
tumors conveniently. Thus, the assembly strategy enables this hybrid bioplaster to hold great potential for skin-related
tumor treatment.