Abstract | BACKGROUND: METHODS: We used bioinformatic methods to explore the potential function of TRIM family genes in the HCC. Web servers ONCOMINE, UALCAN, GEPIA, cBioPortal, STRING, DAVID 6.8 and TIMER were used in this research. RESULTS: We screened TRIM1-76 and found the expressions of TRIM6, TRIM11, TRIM16, TRIM18(MID1), TRIM24, TRIM28, TRIM31, TRIM37, TRIM45, TRIM52, TRIM59, TRIM66 were significantly changed in HCC. Among them, TRIM24, TRIM28, TRIM37, TRIM45 and TRIM59 had significant effects on pathological stages, overall survival and disease free survival. Functions of these genes are primarily related to transcriptional misregulation in cancer, p53 signaling pathway, alcoholism and viral carcinogenesis, FoxO signal pathway, PI3K-AKT pathway, cell cycle, microRNAs in cancer. Our results showed the significant correlation between TRIMs expression and infiltration of innate immune cells (macrophages, neutrophils, and dendritic cells). CONCLUSION: Our result provides novel insights into the function of TRIM family genes, which may be used as potential references for drug targets and accurate survival predictions in patients with HCC.
|
Authors | Hao Su, Yueheng Tang, Kexin Nie, Zhi Wang, Hongzhan Wang, Hui Dong, Gang Chen |
Journal | International journal of general medicine
(Int J Gen Med)
Vol. 15
Pg. 1349-1363
( 2022)
ISSN: 1178-7074 [Print] New Zealand |
PMID | 35173473
(Publication Type: Journal Article)
|
Copyright | © 2022 Su et al. |