Risk factors of unexplained early neurological deterioration after treatment for ischemic stroke due to large vessel occlusion: a post hoc analysis of the HERMES study.

Abstract

BACKGROUND:

Early neurological deterioration (END) after endovascular treatment (EVT) in patients with anterior circulation acute ischemic stroke (AIS) is associated with poor outcome. END may remain unexplained by parenchymal hemorrhage (UnEND). We aim to analyze the risk factors of UnEND in the medical management (MM) and EVT arms of the HERMES study.

METHODS:

We conducted a post-hoc analysis of anterior AIS patients who underwent EVT for proximal anterior occlusions. Risk factors of UnEND, defined as a worsening of ≥4 points between baseline National Institutes of Health Stroke Scale (NIHSS) and NIHSS at 24 hours without hemorrhage, were compared between both arms using mixed logistic regression models adjusted for baseline characteristics. An interaction analysis between the EVT and MM arms for risk factors of UnEND was conducted.

RESULTS:

Among 1723 patients assessable for UnEND, 160 patients experienced an UnEND (9.3%), including 9.1% (78/854) in the EVT arm and 9.4% (82/869) in the MM arm. There was no significant difference in the incidence of UnEND between the two study arms. In the EVT population, independent risk factors of UnEND were lower baseline NIHSS, higher baseline glucose, and lower collateral grade. In the MM population, the only independent predictor of UnEND was higher baseline glucose. However, we did not demonstrate an interaction between EVT and MM for baseline factors as risk factors of UnEND. UnEND was, similarly in both treatment groups, a significant predictor of unfavorable outcome in both the EVT (p<0.001) and MM (p<0.001) arms.

CONCLUSIONS:

UnEND is not an uncommon event, with a similar rate which ever treatment arm is considered. In the clinical scenario of AIS due to large vessel occlusion, no patient-related factor seems to increase the risk for UnEND when treated by EVT compared with MM.

• Authors: Romain Bourcier, Mayank Goyal, Keith W Muir, Hubert Desal, Diederik W J Dippel, Charles B L M Majoie, Wim H van Zwam, Tudor G Jovin, Peter J Mitchell, Andrew M Demchuk, Robert J van Oostenbrugge, Scott B Brown, Bruce Campbell, Philip White, Michael D Hill, Jeffrey L Saver, Christian Weimar, Reza Jahan, Francis Guillemin, Serge Bracard, Olivier Naggara, HERMES Trialists Collaboration
• Journal: Journal of neurointerventional surgery (J Neurointerv Surg) Vol. 15 Issue 3 Pg. 221-226 (Mar 2023) ISSN: 1759-8486 [Electronic] England
• PMID: 35169030 (Publication Type: Journal Article)
• Copyright: © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Glucose

Topics

• Humans
• Stroke (diagnostic imaging, etiology, therapy)
• Ischemic Stroke (therapy, complications)
• Brain Ischemia (diagnostic imaging, etiology, therapy)
• Thrombectomy (adverse effects)
• Treatment Outcome
• Endovascular Procedures (adverse effects)
• Risk Factors
• Glucose (therapeutic use)