Abstract | CONTEXT: The kynurenine pathway generates metabolites integral to energy metabolism, neurotransmission, and immune function. Circulating kynurenine metabolites positively correlate with adiposity in children and adults, yet it is not known whether this relationship is present already at birth. OBJECTIVE: In this prospective longitudinal study, we investigate the relationship between cord blood kynurenine metabolites and measures of adiposity from birth to 4.5 years. METHODS: Liquid chromatography-tandem mass spectrometry was used to quantify cord blood kynurenine metabolites in 812 neonates from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study. Fat percentage was measured by air displacement plethysmography and abdominal adipose tissue compartment volumes; superficial (sSAT) and deep subcutaneous (dSAT) and internal adipose tissue were quantified by magnetic resonance imaging at early infancy in a smaller subset of neonates, and again at 4 to 4.5 years of age. RESULTS: CONCLUSION:
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Authors | Karen Mei-Ling Tan, Mya-Thway Tint, Narasimhan Kothandaraman, Navin Michael, Suresh Anand Sadananthan, S Sendhil Velan, Marielle V Fortier, Fabian Yap, Kok Hian Tan, Peter D Gluckman, Yap-Seng Chong, Mary F F Chong, Yung Seng Lee, Keith M Godfrey, Johan G Eriksson, David Cameron-Smith |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 107
Issue 6
Pg. e2464-e2473
(05 17 2022)
ISSN: 1945-7197 [Electronic] United States |
PMID | 35150259
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. |
Chemical References |
- Kynurenine
- Quinolinic Acid
- Kynurenic Acid
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Topics |
- Adiposity
- Adult
- Birth Weight
- Cesarean Section
- Child
- Child, Preschool
- Female
- Fetal Blood
(metabolism)
- Humans
- Infant
- Infant, Newborn
- Kynurenic Acid
(metabolism)
- Kynurenine
- Longitudinal Studies
- Pediatric Obesity
(metabolism)
- Pregnancy
- Prospective Studies
- Quinolinic Acid
(metabolism)
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