Marginal zone B cells acquire dendritic cell functions by trogocytosis.

Abstract	Marginal zone (MZ) B cells produce broad-spectrum antibodies that protect against infection early in life. In some instances, antibody production requires MZ B cells to display pathogen antigens bound to major histocompatibility complex class II (MHC II) molecules to T cells. We describe the trogocytic acquisition of these molecules from conventional dendritic cells (cDCs). Complement component 3 (C3) binds to murine and human MHC II on cDCs. MZ B cells recognize C3 with complement receptor 2 (CR2) and trogocytose the MHC II-C3 complexes, which become exposed on their cell surface. The ubiquitin ligase MARCH1 limits the number of MHC II-C3 complexes displayed on cDCs to prevent their elimination through excessive trogocytosis. Capture of C3 by MHC II thus enables the transfer of cDC-like properties to MZ B cells.
Authors	Patrick Schriek, Alan C Ching, Nagaraj S Moily, Jessica Moffat, Lynette Beattie, Thiago M Steiner, Laine M Hosking, Joshua M Thurman, V Michael Holers, Satoshi Ishido, Mireille H Lahoud, Irina Caminschi, William R Heath, Justine D Mintern, Jose A Villadangos
Journal	Science (New York, N.Y.) (Science) Vol. 375 Issue 6581 Pg. eabf7470 (02 11 2022) ISSN: 1095-9203 [Electronic] United States
PMID	35143312 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	C3 protein, human Complement C3 HLA-D Antigens Histocompatibility Antigens Class II Receptors, Complement 3d MARCH1 protein, mouse MARCHF1 protein, human Ubiquitin-Protein Ligases
Topics	Adult Animals Antigen Presentation B-Lymphocytes (immunology, metabolism) Cell Membrane (metabolism) Complement Activation Complement C3 (immunology, metabolism) Dendritic Cells (immunology, metabolism) Female HLA-D Antigens (immunology, metabolism) Histocompatibility Antigens Class II (metabolism) Humans Lymphoid Tissue (immunology) Male Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Middle Aged Receptors, Complement 3d (immunology, metabolism) T-Lymphocytes (immunology) Trogocytosis Ubiquitin-Protein Ligases (genetics, metabolism) Ubiquitination

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