The Movember Global Action Plan 1 (GAP1): Unique Prostate Cancer Tissue Microarray Resource.

Abstract

BACKGROUND:

The need to better understand the molecular underpinnings of the heterogeneous outcomes of patients with prostate cancer is a pressing global problem and a key research priority for Movember. To address this, the Movember Global Action Plan 1 Unique tissue microarray (GAP1-UTMA) project constructed a set of unique and richly annotated tissue microarrays (TMA) from prostate cancer samples obtained from multiple institutions across several global locations.

METHODS:

Three separate TMA sets were built that differ by purpose and disease state.

RESULTS:

The intended use of TMA1 (Primary Matched LN) is to validate biomarkers that help determine which clinically localized prostate cancers with associated lymph node metastasis have a high risk of progression to lethal castration-resistant metastatic disease, and to compare molecular properties of high-risk index lesions within the prostate to regional lymph node metastases resected at the time of prostatectomy. TMA2 (Pre vs. Post ADT) was designed to address questions regarding risk of castration-resistant prostate cancer (CRPC) and response to suppression of the androgen receptor/androgen axis, and characterization of the castration-resistant phenotype. TMA3 (CRPC Met Heterogeneity)'s intended use is to assess the heterogeneity of molecular markers across different anatomic sites in lethal prostate cancer metastases.

CONCLUSIONS:

The GAP1-UTMA project has succeeded in combining a large set of tissue specimens from 501 patients with prostate cancer with rich clinical annotation.

IMPACT:

This resource is now available to the prostate cancer community as a tool for biomarker validation to address important unanswered clinical questions around disease progression and response to treatment.

• Authors: Véronique Ouellet, Andrew Erickson, GAP1 UTMAs Contributing Investigators, Kathy Wiley, Colm Morrissey, Viktor Berge, Carlos S Moreno, Kristin Austlid Tasken, Dominique Trudel, Lawrence D True, Michael S Lewis, Aud Svindland, Onur Ertunc, Igor Damasceno Vidal, Adeboye O Osunkoya, Tracy Jones, G Steven Bova, Tarja Lamminen, Ariel H Achtman, Mark Buzza, Michelle M Kouspou, Steven A Bigler, Xinchun Zhou, Stephen J Freedland, Anne-Marie Mes-Masson, Isla P Garraway, Bruce J Trock, Pekka Taimen, Fred Saad, Tuomas Mirtti, Beatrice S Knudsen, Angelo M De Marzo
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 31 Issue 4 Pg. 715-727 (04 01 2022) ISSN: 1538-7755 [Electronic] United States
• PMID: 35131885 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: ©2022 The Authors; Published by the American Association for Cancer Research.

Topics

• Humans
• Male
• Prostate (pathology)
• Prostatectomy
• Prostatic Neoplasms, Castration-Resistant