Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone.

Abstract

One hundred seventy-one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12.5, 25.0, or 50.0 mg or placebo once daily for 12 weeks. The majority of the patients receiving chlorthalidone 12.5 mg achieved therapeutic success with no clinically significant biochemical changes or side effects. The 50.0-mg dose level enhanced efficacy only minimally over the 25.0-mg dose level. Drug-related side effects were significantly more prevalent in the chlorthalidone 50.0-mg group than in the placebo group. The data suggest that most elderly patients with isolated systolic hypertension, regardless of the severity, could be treated effectively and safely with chlorthalidone 12.5 mg per day.

• Authors: J H Morledge, B Ettinger, J Aranda, F McBarron, P Barra, J Gorwit, M Davidov
• Journal: Journal of the American Geriatrics Society (J Am Geriatr Soc) Vol. 34 Issue 3 Pg. 199-206 (Mar 1986) ISSN: 0002-8614 [Print] United States
• PMID: 3512670 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Uric Acid
• Cholesterol
• Chlorthalidone
• Potassium

Topics

• Age Factors
• Aged
• Blood Glucose (analysis)
• Body Weight
• Chlorthalidone (administration & dosage, adverse effects)
• Cholesterol (blood)
• Clinical Trials as Topic
• Dose-Response Relationship, Drug
• Double-Blind Method
• Electrocardiography
• Female
• Humans
• Hypertension (drug therapy)
• Hypokalemia (chemically induced)
• Male
• Middle Aged
• Potassium (blood)
• Pulse
• Systole (drug effects)
• Uric Acid (blood)