Improvement of pneumonia by curcumin-loaded bionanosystems based on platycodon grandiflorum polysaccharides via calming cytokine storm.

Abstract

Pneumonia can lead to high morbidity and mortality secondary to uncontrolled inflammation of the lung tissue. Blocking cytokine storm storms may be the key to saving the life of patients with severe pneumonia. According to the medicinal guide theory of Traditional Chinese Medicine (TCM) and the inherent affinity with macrophages for the site of inflammation, we constructed the drug delivery platform (MNPs) derived from macrophage-membrane encapsulated reaction oxygen species (ROS)-responsive Platycodon grandiflorum polysaccharides (PGP) nanoparticles (PNPs) to calm the cytokine storm and improve lung inflammation. By loading the anti-inflammatory agent Curcumin (Cur), we demonstrated that MNPs@Cur significantly attenuated inflammation and cytokine storm syndrome in acute lung injury (ALI) mice by suppressing pro-inflammatory factor production and inflammatory cell infiltration. Interestingly, we observed that the PNPs also have potent pulmonary targeting ability compared to other polysaccharide carriers, which is in line with the medicinal guide theory of TCM. Our study revealed the rational design of drug delivery platforms to improve the treatment of lung injury, which inherits and develops the important theories of TCM through the perfect combination of guide theory and biomimetic nanotechnology and provides the experimental scientific basis for the clinical application of channel ushering drugs.

• Authors: Yi Li, Chunjing Guo, Qiang Chen, Yanguo Su, Huimin Guo, Ruoyang Liu, Changgang Sun, Shuqi Mi, Jinqiu Wang, Daquan Chen
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 202 Pg. 691-706 (Mar 31 2022) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 35124019 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Chemical References

• Polysaccharides
• Curcumin

Topics

• Animals
• Curcumin (pharmacology)
• Cytokine Release Syndrome
• Humans
• Mice
• Platycodon
• Pneumonia (drug therapy)
• Polysaccharides