Treatment of recalcitrant Acanthamoeba Keratitis with Photoactivated Chromophore for Infectious Keratitis Corneal Collagen Cross-Linking (PACK-CXL).

Abstract

PURPOSE:

To describe a case of recalcitrant Acanthamoeba Keratitis (AK) complicated by medical non-compliance and medication intolerance that was successfully treated with photoactivated chromophore for infectious keratitis corneal collagen cross-linking (PACK-CXL).

OBSERVATIONS:

A 31-year-old male presented with right eye pain and redness in the setting of fresh water exposure and scleral contact lens wear. He had lack of a response to treatment with antiviral therapy for 3 months by an outside provider. Cultures were found to be positive for Acanthamoeba and the patient was treated with an extended course of various anti-amoebic therapies with poor compliance due to pain and toxicity. He was eventually treated with intrastromal voriconazole and Miltefosine without improvement and eventually had PACK-CXL with resolution of his infection and pain.

CONCLUSION:

PACK-CXL was associated with a dramatic improvement in a case of recalcitrant Acanthamoeba keratitis unresponsive to both traditional and novel therapies and may be a viable alternative or adjunctive therapy for Acanthamoeba keratitis.

• Authors: Shelly H Watson, Nakul S Shekhawat, Yassine J Daoud
• Journal: American journal of ophthalmology case reports (Am J Ophthalmol Case Rep) Vol. 25 Pg. 101330 (Mar 2022) ISSN: 2451-9936 [Electronic] United States
• PMID: 35112032 (Publication Type: Case Reports)
• Copyright: © 2022 Published by Elsevier Inc.