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From the dish to humans: A stem cell recipe for success.

Abstract
Islet transplantation has proven to be an effective treatment for type 1 diabetes (T1D) yet is hampered by the shortage of available tissue. Recently, two reports from a Viacyte multicenter clinical trial demonstrate the feasibility, safety, and potential efficacy of transplanting macro-encapsulated human stem cell-derived pancreatic endoderm cells into patients with T1D, highlighting the promise of a stem cell-based therapeutic approach.
AuthorsHolger A Russ, Ali H Shilleh, Lori Sussel
JournalCell metabolism (Cell Metab) Vol. 34 Issue 2 Pg. 193-196 (02 01 2022) ISSN: 1932-7420 [Electronic] United States
PMID35108510 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Comment)
CopyrightCopyright © 2022 Elsevier Inc. All rights reserved.
Topics
  • Cell Differentiation
  • Diabetes Mellitus, Type 1 (therapy)
  • Endoderm
  • Humans
  • Islets of Langerhans Transplantation
  • Stem Cells

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