Radiotherapy for patients with Ledderhose disease: Long-term effects, side effects and patient-rated outcome.

Abstract

BACKGROUND:

The purpose of this study was to investigate the long-term effects of radiotherapy for patients with Ledderhose disease.

METHODS:

Questionnaires were sent to all patients with Ledderhose disease who had been treated with radiotherapy at our centre between 2008 and 2017 and who consented to participate. Radiotherapy was performed with orthovolt or electrons in two separate courses of five daily fractions of 3 Gy. The questionnaires addressed items such as pain from Ledderhose disease (Brief Pain Inventory), quality of life (EURO-QOL-5D-5L), long-term side effects, and patients' levels of satisfaction with the effect of treatment. Descriptive statistics and non-parametric tests were used to analyse the results.

RESULTS:

A total of 102 feet were irradiated in 67 patients (28 men, 39 women). Radiotherapy resulted in significant pain reduction: the mean pain score prior to radiotherapy, collected retrospectively, was 5.7 and 1.7 at time of assessment (p-value < 0.001). The following pain response scores were reported: progressive pain (0%), no change (22%; 22 feet), partial pain response (37%; 38 feet) and complete pain response (absence of pain) (41%; 42 feet). Seventy-eight percent of patients were satisfied with the treatment effect and 57% did not consider radiotherapy burdensome. The scores for societal perspective (0.856) and patients' perspective on quality of life (82.3) were each comparable to the reference values from the Dutch population in the same age category (0.857 and 80.6, respectively). The most commonly reported residual long-term side effect was dryness of the skin (n = 10; 15%).

CONCLUSION:

Radiotherapy for Ledderhose disease results in long-term pain reduction in the majority of patients and has limited side effects. The treatment is well tolerated, patients feel satisfied, and quality of life is comparable to the reference population.

• Authors: Anneke de Haan, Johanna G H van Nes, Paul M N Werker, Johannes A Langendijk, Roel J H M Steenbakkers
• Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Radiother Oncol) Vol. 168 Pg. 83-88 (03 2022) ISSN: 1879-0887 [Electronic] Ireland
• PMID: 35101465 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Topics

• Female
• Fibromatosis, Plantar (therapy)
• Humans
• Male
• Pain
• Pain Measurement
• Quality of Life
• Retrospective Studies
• Treatment Outcome