Abstract |
Pituitary neuroendocrine tumors (PitNET) are commonly benign tumors accounting for 10-25% of intracranial tumors. Prolactin-secreting adenomas represent the most predominant type of all PitNET and for this subtype of tumors, the medical therapy relies on the use of dopamine agonists ( DAs). DAs yield an excellent therapeutic response in reducing tumor size and hormonal secretion targeting the dopamine receptor type 2 (D2DR) whose higher expression in prolactin-secreting adenomas compared to other PitNET is now well established. Moreover, although DAs therapy does not represent the first-line therapy for other PitNET, off-label use of DAs is considered in PitNET expressing D2DR. Nevertheless, DAs primary or secondary resistance, occurring in a subset of patients, may involve several molecular mechanisms, presently not fully elucidated. Dopamine receptors (DRs) expression is a prerequisite for a proper DA function in PitNET and several molecular events may negatively modify DR membrane expression, through the DRs down-regulation and intracellular trafficking, and DR signal transduction pathway. The current mini-review will summarise the presently known molecular events that underpin the unsuccessful therapy with DAs.
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Authors | Claudia Pivonello, Roberta Patalano, Mariarosaria Negri, Rosa Pirchio, Annamaria Colao, Rosario Pivonello, Renata Simona Auriemma |
Journal | Frontiers in endocrinology
(Front Endocrinol (Lausanne))
Vol. 12
Pg. 791633
( 2021)
ISSN: 1664-2392 [Print] Switzerland |
PMID | 35095761
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2022 Pivonello, Patalano, Negri, Pirchio, Colao, Pivonello and Auriemma. |
Chemical References |
- Aminoquinolines
- Dopamine Agonists
- Filamins
- MicroRNAs
- Receptors, Dopamine D2
- beta-Arrestins
- Pergolide
- Bromocriptine
- quinagolide
- Lisuride
- Cabergoline
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Topics |
- ACTH-Secreting Pituitary Adenoma
(drug therapy, metabolism)
- Adenoma
(drug therapy, metabolism)
- Aminoquinolines
(therapeutic use)
- Bromocriptine
(therapeutic use)
- Cabergoline
(therapeutic use)
- Dopamine Agonists
(therapeutic use)
- Drug Resistance, Neoplasm
- Filamins
(metabolism)
- Growth Hormone-Secreting Pituitary Adenoma
(drug therapy, metabolism)
- Humans
- Lisuride
(therapeutic use)
- MicroRNAs
(metabolism)
- Pergolide
(therapeutic use)
- Pituitary Neoplasms
(drug therapy, metabolism)
- Prolactinoma
(drug therapy, metabolism)
- Receptors, Dopamine D2
(agonists, metabolism)
- beta-Arrestins
(metabolism)
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