Efficacy of a Carrageenan Gel in Increasing Clearance of Anal Human Papillomavirus Infections in Men: Interim Analysis of a Double-Blind, Randomized Controlled Trial.

Abstract

Preclinical studies have demonstrated carrageenan's anti-human papillomavirus (HPV) activity. We assessed efficacy of a carrageenan-based gel compared to a placebo gel in increasing the clearance of anal HPV infections among gay, bisexual, and other men who have sex with men (gbMSM). Of 255 enrolled gbMSM, 134 were HPV positive at baseline and had valid HPV results for ≥2 visits. Carrageenan did not differ from placebo in clearing all baseline infections (hazard ratio, 0.84 [95% confidence interval, .31-2.27]), based on having 2 consecutive HPV-negative visits following at least 1 HPV-positive visit. There were no remarkable differences for analyses at the HPV type level or by human immunodeficiency virus status.

CLINICAL TRIALS REGISTRATION:

NCT02354144.

• Authors: Cassandra Laurie, Mariam El-Zein, Joseph Tota, Farzin Khosrow-Khavar, Pierre-Paul Tellier, François Coutlée, Alexandra de Pokomandy, Eduardo L Franco, Lubricant Investigation in Men to Inhibit Transmission of Human Papillomavirus Infection (LIMIT-HPV) Study Group
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 227 Issue 3 Pg. 402-406 (02 01 2023) ISSN: 1537-6613 [Electronic] United States
• PMID: 35090175 (Publication Type: Randomized Controlled Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Chemical References

• Carrageenan

Topics

• Male
• Humans
• Papillomavirus Infections
• Homosexuality, Male
• Carrageenan
• Sexual and Gender Minorities
• Anal Canal
• Human Papillomavirus Viruses
• HIV Infections
• Papillomaviridae