Abstract | BACKGROUND: METHODS: We conducted a systematic review and meta-analysis of reports on the impact of MDA on scabies and impetigo. We included randomized control trials and observational evaluations reported from January 1970 to April 2021 and involving human participants. We searched PubMed, Ovid Medline, Embase, and Cochrane. We considered MDA as treatment intended for the whole population, regardless of individual infection status or symptoms. The main outcome assessed was the change in scabies and impetigo prevalence following MDA. This review is registered with PROSPERO (CRD42020169839). RESULTS: We identified 1110 records, of which 11 met inclusion criteria for the review and 9 were deemed suitable for meta-analysis for scabies and 4 for impetigo. Most studies were in small populations. There was a high degree of heterogeneity between studies (I2 value 96.19%). The overall relative reduction of the impact of MDA on scabies prevalence was 79%. The effect size was comparable for MDA based on ivermectin and permethrin. MDA for scabies also led to a reduction in impetigo prevalence with a relative reduction of 66%. CONCLUSIONS: MDA for scabies is highly effective in reducing the prevalence of scabies and impetigo. Further research is needed to determine the durability of impact, and the effectiveness of MDA regimens in larger populations.
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Authors | Susanna J Lake, John M Kaldor, Myra Hardy, Daniel Engelman, Andrew C Steer, Lucia Romani |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 75
Issue 6
Pg. 959-967
(09 29 2022)
ISSN: 1537-6591 [Electronic] United States |
PMID | 35088849
(Publication Type: Journal Article, Meta-Analysis, Systematic Review, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. |
Chemical References |
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Topics |
- Humans
- Impetigo
(drug therapy, epidemiology, prevention & control)
- Ivermectin
(therapeutic use)
- Mass Drug Administration
- Neglected Diseases
(drug therapy)
- Permethrin
(therapeutic use)
- Scabies
(drug therapy, epidemiology, prevention & control)
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