Abstract | OBJECTIVE: METHODS: A total of 120 children with a mean age of 12 years were enrolled in the study. Blood samples were collected to assess the circulating levels of neuropeptides and were correlated with various anthropometric, clinical, and metabolic markers. RESULTS: Plasma levels of UCNs were altered in children with overweight but less so in those with obesity. Furthermore, the expression pattern of UCN1 was opposite to that of UCN2 and UCN3, which suggests a compensatory effect. However, no significant effect of overweight and obesity was observed on CRH and spexin levels. Finally, UCN3 independently associated with circulating zinc-alpha-2-glycoprotein and UCN2 levels, whereas UCN1 was strongly predicted by TNFα levels. CONCLUSIONS: Significant changes in neuropeptide levels were primarily observed in children with overweight and were attenuated with increased obesity. This suggests the presence of a compensatory mechanism for neuropeptides to curb the progression of obesity.
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Authors | Sina Kavalakatt, Abdelkrim Khadir, Dhanya Madhu, Sriraman Devarajan, Samia Warsame, Hessa AlKandari, Maria AlMahdi, Heikki A Koistinen, Fahd Al-Mulla, Jaakko Tuomilehto, Jehad Abubaker, Ali Tiss |
Journal | Obesity (Silver Spring, Md.)
(Obesity (Silver Spring))
Vol. 30
Issue 2
Pg. 472-481
(02 2022)
ISSN: 1930-739X [Electronic] United States |
PMID | 35088550
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS). |
Chemical References |
- Receptors, Corticotropin-Releasing Hormone
- Urocortins
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Topics |
- Animals
- Child
- Humans
- Mammals
(metabolism)
- Obesity
- Overweight
- Receptors, Corticotropin-Releasing Hormone
(metabolism)
- Urocortins
(metabolism, pharmacology)
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